rebbarb/docs/Environment/Amaranth-Hdl project setup.md

Create a venv python -m venv .venv

Activate the venv . .vent/bin/activate

Install the dependencies pip install -r requirements.txt

You will potentially need more tooling to create the bitstream and flash the bitstream for the specific FPGA. In my case I'm working with an IceBreaker. So I've installed the nextpnr-ice40 toolchain. Yosys is builtin to amaranth, that is why I'm running it within an venv to ensure it doesn't mess with system installed packages.